n−3 Polyunsaturated fatty acids raise low-density lipoproteins, high-density lipoprotein 2, and plasminogen-activator inhibitor in healthy young men
| Autor: | Fathi Driss, H J Parra, Véronique Ollivier, Frédéric Fumeron, P Darcet, Marian Apfelbaum, Jean-Charles Fruchart, J.M. Bard, L Brigant, D. de Prost |
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| Rok vydání: | 1991 |
| Předmět: |
Adult
Male medicine.medical_specialty Calorie Platelet Aggregation Medicine (miscellaneous) Lipoproteins VLDL Biology Cholesterol Dietary chemistry.chemical_compound Fish Oils Internal medicine Fatty Acids Omega-3 medicine Humans Triglycerides chemistry.chemical_classification Nutrition and Dietetics Cholesterol Metabolism Fish oil Dietary Fats Lipoproteins LDL Plasminogen Inactivators Endocrinology chemistry Hemostasis lipids (amino acids peptides and proteins) Energy Intake Lipoproteins HDL Plasminogen activator Platelet Aggregation Inhibitors Lipoprotein Polyunsaturated fatty acid |
| Zdroj: | Europe PubMed Central Scopus-Elsevier |
| ISSN: | 0002-9165 |
| DOI: | 10.1093/ajcn/54.1.118 |
| Popis: | The effects ofa moderate supplementation in n-3 polyunsaturated fatty acids (PUFAs) were investigated in 36 young healthy adult males. Factors investigated were lipo- protein (including HDL subfractions and apolipoproteins) and hemostasis indexes, assessed by platelet aggregation and plas- minogen-activator-inhibitor (PA!) activity. Fat-controlled diets were prescribed, one with and one without a fish-oil supplement (control diet), successively during 3 wk in random order. Total calorie, fat, and cholesterol intakes were similar in the two diets. Triglycerides in serum and very-low-density lipoproteins were lower and high-density-lipoprotein 2 cholesterol was higher with the n-3 PUFA-supplemented diet. These effects as well as a significant decrease in platelet aggregation can be considered beneficial in terms of cardiovascular risk. However, significant increases in low-density-lipoprotein cholesterol and PAl activity occurred and were correlated. This latter effect could be detri- mental. Am J Clin Nutr 1991;54:l 18-22. |
| Databáze: | OpenAIRE |
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