Sustained Atrial Flutter Around the Tricuspid Valve in Pigs
| Autor: | Hjgm Crijns, Tjark Ebels, Kj Bel, Ki Lie, Harry Wesseling, Cdj Delangen, JG Grandjean |
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| Rok vydání: | 1993 |
| Předmět: |
Male
Quinidine medicine.medical_specialty Swine Refractory period Diastole Procainamide Nerve conduction velocity Electrocardiography Heart Conduction System Internal medicine medicine Animals Flecainide Pharmacology Fibrillation business.industry medicine.disease Endocrinology Atrial Flutter Cardiology Tricuspid Valve medicine.symptom Cardiology and Cardiovascular Medicine business Atrial flutter medicine.drug |
| Zdroj: | Journal of Cardiovascular Pharmacology. 21:462-470 |
| ISSN: | 0160-2446 |
| Popis: | The wavelength theory considers two determinants of reentry, i.e., refractoriness and conduction velocity. It does not take excitability into account primarily. We evaluated frequency-dependence of excitability and refractoriness before and after flecainide or procainamide administration in relation to termination of reentrant atrial flutter. After making a Y-shaped lesion in the right atrium, we induced 62 flutters (cycle length 171 +/- 15 ms) by electrical stimulation in 15 pigs. Strength-interval curves were determined to assess excitability and refractoriness. Multiple cycle lengths were used to establish rate-dependent changes. Flutter cycle length increased after flecainide (to 290 +/- 67 ms) or procainamide (to 295 +/- 54 ms). The flutters always terminated abruptly (flecainide dose 103 +/- 104 mg, plasma concentration 370 +/- 21 ng/ml; procainamide dose 1,150 +/- 686 mg, concentration 51 +/- 24 mg/l). Flecainide caused an increase in diastolic thresholds from 0.3 +/- 0.2 to 0.8 +/- 0.5 mA (p |
| Databáze: | OpenAIRE |
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