Chronic effects of oral sulindac on renal haemodynamics and hormones in subjects with chronic renal disease
| Autor: | Charles P. Swainson, Peter Griffiths, Michael Watson |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.drug_class Urinary system Renal function Kidney urologic and male genital diseases Plasma renin activity Dinoprostone chemistry.chemical_compound Sulindac Internal medicine Renin medicine Humans Aldosterone Aged business.industry Prostaglandins E Hemodynamics General Medicine Effective renal plasma flow Middle Aged Endocrinology Indenes chemistry Mineralocorticoid Kidney Failure Chronic Female business Hormone medicine.drug |
| Zdroj: | Clinical Science. 70:243-247 |
| ISSN: | 1470-8736 0143-5221 |
| Popis: | 1. The effects of oral sulindac, 600 mg daily, on renal function and plasma hormones were studied in eight subjects with chronic renal failure. 2. Renal function and plasma hormones were measured before drug administration and then after taking sulindac for 28 days. 3. Effective renal plasma flow was reduced in all subjects after 28 days but the glomerular filtration rate did not change. 4. Plasma renin activity, potassium and aldosterone concentrations and urinary sodium excretion did not change but urinary prostaglandin E2 excretion fell significantly. 5. Sulindac may be a relatively renal-sparing drug in its effects on the hormonal control of glomerular function. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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