The in vitro development of extended-release solid oral dosage forms
| Autor: | Nora Chiang, James Clevenger, Dennis Adair, Lewis J. Leeson |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Dosage Forms
Chromatography Chemistry Pharmacology toxicology Administration Oral Pharmacology Controlled release Dosage form Pharmacokinetics Solubility Delayed-Action Preparations Technology Pharmaceutical Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics Extended release Tablets |
| Zdroj: | Journal of pharmacokinetics and biopharmaceutics. 13(5) |
| ISSN: | 0090-466X |
| Popis: | A system is described for developing extended-release products, based upon predicting or simulating the entire plasma level-time curve to be expected from the administration of a controlled-release oral dosage form. Termed "biorelevant dissolution," it employs the product's in vitro dissolution behavior and the drug's pharmacokinetic parameters in conjunction with a classical pharmacokinetic model. The basic system is described along with some pertinent examples. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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