Ambruticin S production in air-lift and stirred-tank bioreactors
| Autor: | Norbert W. Hopf, Wolf-Dieter Deckwer, Sems Yonsel |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Alanine
Antifungal Agents Oxygen transfer biology business.industry Chemistry Ambruticin S General Medicine AMBRUTICIN Carbon Dioxide biology.organism_classification Pulp and paper industry Applied Microbiology and Biotechnology Mycobacterium Biotechnology Oxygen Lift (force) Fermentation Bioreactor Aeration business Pyrans Sorangium cellulosum |
| Zdroj: | Applied Microbiology and Biotechnology. 34 |
| ISSN: | 1432-0614 0175-7598 |
| DOI: | 10.1007/bf00170057 |
| Popis: | Using the method of equi-inocular synchronized comparative fermentation (EISCF) the cultivation of Sorangium cellulosum So ce 10 and production of the polyketide antibiotic ambruticin S was compared in stirred-tank and air-lift reactors of different geometry. This method requires that inocula originate from the same pre-culture and cultivation parameters are synchronized to similar values. Similar ambruticin yields were obtained from both reactor systems provided that the concentration of dissolved oxygen (DO) was maintained above a certain value (ca. 40%). For cultivation of S. cellulosum it is the DO level rather than the oxygen transfer rate which presents the proper criterion for scale-up and comparative reactor studies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink