Expression of stromelysin-3 and nm23 in breast carcinoma and related tissues
| Autor: | Roland Hähnel, Peter Robbins, Hugh Dawkins, Erika Hähnel |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Axillary lymph nodes Biopsy Mammary gland Gene Expression Breast Neoplasms Biology Breast cancer Matrix Metalloproteinase 11 Gene expression Carcinoma medicine Humans Neoplasm Invasiveness Breast RNA Messenger skin and connective tissue diseases Monomeric GTP-Binding Proteins Epithelioma Carcinoma Ductal Breast Metalloendopeptidases NM23 Nucleoside Diphosphate Kinases Ductal carcinoma Blotting Northern medicine.disease medicine.anatomical_structure Oncology Lymphatic Metastasis Nucleoside-Diphosphate Kinase Female Breast carcinoma Carcinoma in Situ Transcription Factors |
| Zdroj: | International Journal of Cancer. 58:157-160 |
| ISSN: | 1097-0215 0020-7136 |
| DOI: | 10.1002/ijc.2910580202 |
| Popis: | Biological functions proposed for the ST3 and nm23 genes in tumour development and progression seem to be directly opposed. Stromelysin-3 (ST3) is a putative member of the matrix metalloproteinase family. ST3 has been implicated in the progression of epithelial malignancies, specifically with regard to an invasive (and therefore potentially metastasizing) phenotype. The nm23 gene, on the other hand, encodes a nucleoside diphosphate kinase which allegedly has a metastasis-suppressor-type function. It was therefore of interest to compare the expression of ST3 and nm23 in various surgically excised normal and neoplastic breast tissues. RNA was isolated from over 200 surgical specimens and studied by Northern blots. Normal breast tissues did not express ST3, and ST3 expression was detected in only 1 of 20 normal axillary lymph nodes. None of 7 fibroadenomas expressed ST3. In contrast, 60% of primary and metastatic breast carcinomas contained ST3-mRNA. The expression of ST3 was mainly confined to invasive carcinomas and was observed less frequently in pure ductal carcinoma in situ (DCIS) lesions. Our results support the suggestion that ST3 expression is related to the malignant process in breast cancer. The role of nm23 is far less clear-cut. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text