MR Spectroscopy Shows Reduced Frontal Lobe Concentrations of N-Acetyl Aspartate in Patients with Juvenile Myoclonic Epilepsy
| Autor: | Gunther Helms, Dan Greitz, Ivanka Savic, Åsa Lekvall |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male In vivo magnetic resonance spectroscopy medicine.medical_specialty Magnetic Resonance Spectroscopy Prefrontal Cortex Choline Lesion Epilepsy medicine Humans Aspartic Acid medicine.diagnostic_test business.industry Myoclonic Epilepsy Juvenile Magnetic resonance imaging Creatine medicine.disease Magnetic Resonance Imaging Frontal Lobe Surgery nervous system Neurology Frontal lobe Myoclonic epilepsy Female Neurology (clinical) medicine.symptom Juvenile myoclonic epilepsy business Nuclear medicine Myoclonus Inositol |
| Zdroj: | Epilepsia. 41:290-296 |
| ISSN: | 1528-1167 0013-9580 |
| DOI: | 10.1111/j.1528-1157.2000.tb00158.x |
| Popis: | Summary: Purpose: Neuropsychological studies suggest frontal lobe dysfunctions in patients with juvenile myoclonic epilepsy (JME). In this study we investigated whether an underlying mechanism could be a regional neuronal damage not visible with structural magnetic resonance (MR), but detectable with magnetic resonance spectroscopy (MRS). Methods: The study included 15 patients with JME and 10 matched healthy controls. Quantitative single voxel MRS was conducted at 1.5 Tesla by using a STEAM sequence (TR/TE/TM = 6,000/30/13.7 ms). The voxels were placed over the right cerebellum, right thalamus, and the prefrontal and occipital cortex. The quantitation included fitting of transmitter gain, and correction for partial volume of cerebrovascular fluid. LC-Model was used for estimation of the absolute concentrations of total N-acetyl aspartate (NAA), cholines, total creatine, and myoinositol. Results: Patients with JME had significantly reduced prefrontal concentrations of NAA in relation to controls (9.1 ± 1.0 vs. 10.2 ± 0.8 mM; p = 0.031 after Bonferroni correction). The other regions showed normal NAA values, as did the other metabolites. Conclusions: The observed reduction in NAA levels suggests a prefrontal neuronal lesion in patients with JME. |
| Databáze: | OpenAIRE |
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