Clinical spectrum of coronavirus disease 2019 in Iceland: population based cohort study
| Autor: | Agnar Bjarnason, Hrafn Hliddal Thorvaldsson, Kristin Oskarsdottir, Dadi Helgason, Ragnar Freyr Ingvarsson, Arnar S Agustsson, Gudrun Kristjansdottir, Lovisa Bjork Olafsdottir, Hrafnhildur Linnet Runolfsdottir, Elias Eythorsson, Valgerdur Bjarnadottir, Solveig Bjarnadottir, Birgir Johannsson, Helgi K Bjornsson, Brynja Armannsdottir, Runolfur Palsson, Olafur S. Indridason, Martin I Sigurdsson, Magnus Gottfredsson, Olafur Gudlaugsson |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
myalgia
Adult Male Pediatrics medicine.medical_specialty Adolescent Iceland Disease Asymptomatic Cohort Studies 03 medical and health sciences Young Adult 0302 clinical medicine Pandemic medicine Humans 030212 general & internal medicine Prospective Studies Young adult Prospective cohort study Child Pandemics 030304 developmental biology Aged 0303 health sciences Self Referral business.industry Research Infant Newborn COVID-19 Infant General Medicine Middle Aged Child Preschool Disease Progression Female medicine.symptom Symptom Assessment business Cohort study |
| Zdroj: | BMJ The BMJ |
| ISSN: | 1756-1833 |
| DOI: | 10.1136/bmj.m4529 |
| Popis: | Objective To characterise the symptoms of coronavirus disease 2019 (covid-19). Design Population based cohort study. Setting Iceland. Participants All individuals who tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by reverse transcription polymerase chain reaction (RT-PCR) between 17 March and 30 April 2020. Cases were identified by three testing strategies: targeted testing guided by clinical suspicion, open invitation population screening based on self referral, and random population screening. All identified cases were enrolled in a telehealth monitoring service, and symptoms were systematically monitored from diagnosis to recovery. Main outcome measures Occurrence of one or more of 19 predefined symptoms during follow-up. Results Among 1564 people positive for SARS-CoV-2, the most common presenting symptoms were myalgia (55%), headache (51%), and non-productive cough (49%). At the time of diagnosis, 83 (5.3%) individuals reported no symptoms, of whom 49 (59%) remained asymptomatic during follow-up. At diagnosis, 216 (14%) and 349 (22%) people did not meet the case definition of the Centers for Disease Control and Prevention and the World Health Organization, respectively. Most (67%) of the SARS-CoV-2-positive patients had mild symptoms throughout the course of their disease. Conclusion In the setting of broad access to RT-PCR testing, most SARS-CoV-2-positive people were found to have mild symptoms. Fever and dyspnoea were less common than previously reported. A substantial proportion of SARS-CoV-2-positive people did not meet recommended case definitions at the time of diagnosis. |
| Databáze: | OpenAIRE |
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