Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential
| Autor: | Qingyu Ma, Xiaojuan Li, Yu-He Lei, Wen-Zhi Hao, Lijuan Deng, Mansi Wu, Jiaxu Chen, Hua Gan, Naijun Yuan, Junqing Huang, Xuan Zhou, Kairui Tang |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Expression of circRNAs Common disease miRNA sponge RM1-950 Biology Bioinformatics 03 medical and health sciences Human health 0302 clinical medicine microRNA Animals Humans Gene Depression (differential diagnoses) Pharmacology Gene knockdown Depression Brain Depression therapy RNA Circular General Medicine Antidepressive Agents Affect MicroRNAs 030104 developmental biology Gene Expression Regulation 030220 oncology & carcinogenesis circRNA function Therapeutics. Pharmacology circRNAs Function (biology) Biogenesis |
| Zdroj: | Biomedicine & Pharmacotherapy, Vol 137, Iss, Pp 111244-(2021) |
| ISSN: | 0753-3322 |
| Popis: | Depression is the second most common disease burden worldwide that threatens human health; however, mechanisms underlying the development of depression remain unclear. A family of non-coding RNAs, circular RNAs (circRNAs), has been shown to play a critical role in the development of depression by competitively binding to certain microRNAs (miRNA) and regulating the expression of target genes. Behavioral symptoms of depression may be ameliorated by knockdown or overexpression of depression-associated circRNAs. In this review, we summarized important functions of circRNAs and analyzed the most recent findings regarding the expression and biological function of circRNAs in depression. We discussed novel circRNA-based strategies to illuminate potential therapeutic targets that may aid in the development of new treatments for depression. |
| Databáze: | OpenAIRE |
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