Bioinspired reconfiguration of 3D printed microfluidic hydrogels via automated manipulation of magnetic inks
| Autor: | Luiz E. Bertassoni, Amin Mansoorifar, Anthony Tahayeri |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Fabrication
Materials science Microfluidics Biomedical Engineering Bioengineering Nanotechnology 02 engineering and technology Biochemistry Article 03 medical and health sciences chemistry.chemical_compound Humans Microparticle 030304 developmental biology 0303 health sciences Magnetic Phenomena Reconfigurability Control reconfiguration Hydrogels General Chemistry 021001 nanoscience & nanotechnology chemistry Magnet Printing Three-Dimensional Self-healing hydrogels Agarose Ink 0210 nano-technology |
| Zdroj: | Lab Chip |
| ISSN: | 1473-0189 1473-0197 |
| DOI: | 10.1039/d0lc00280a |
| Popis: | One of the key components in controlling fluid streams in microfluidic devices is the valve and gating modules. In most of the situations, these components are fixed at specific locations, and new reconfiguration of microchannels requires costly and laborious fabrication of new devices. In this study, inspired by human vasculature microcapillary reconfiguration in response to blood transport requirements, the idea of reconfigurable gel microfluidic systems is presented for the first time. A simple approach is described to print microchannels in methacrylated gelatin (GelMA) hydrogels by using agarose fibers that are loaded with iron microparticles. The agarose fibers can then be used as valves, which are then manipulated using a permanent magnet, providing the reconfigurability of the system. The feasibility of agarose gels is tested with different iron microparticles loadings as well as its resistance to fluid flows. Further, it is shown that using this technique, multiple configurations, as well as reconfigurability, are possible from a single device. This work opens the framework to design more intricate and reconfigurable microfluidic devices, which will decrease the cost and size of the final product. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|