Magnetic Resonance Imaging of Cardiac Allografts: What's Next?
| Autor: | Majd Ibrahim, James C. Fang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Heart transplantation
medicine.diagnostic_test business.industry Gadolinium medicine.medical_treatment chemistry.chemical_element Magnetic resonance imaging Allografts Prognosis Fibrosis Magnetic Resonance Imaging Article Nuclear magnetic resonance chemistry cardiovascular system Medicine Heart Transplantation Humans Radiology Nuclear Medicine and imaging cardiovascular diseases Cardiology and Cardiovascular Medicine business |
| Zdroj: | Circ Cardiovasc Imaging |
| ISSN: | 1942-0080 |
| Popis: | BACKGROUND: Myocardial fibrosis is a well-described histopathological feature in heart transplant recipients. Whether myocardial fibrosis in heart transplant recipients is independently associated with clinical outcomes is unclear. We sought to determine whether myocardial fibrosis on late gadolinium enhancement cardiovascular magnetic resonance imaging (LGE CMR) in heart transplant recipients was independently associated with all-cause death or major adverse cardiac outcomes in the long term. METHODS: Using a cohort of consecutive heart transplant recipients that had CMR, we determined the prevalence and the patterns of myocardial fibrosis and analyzed associations between myocardial fibrosis and a composite endpoint of all-cause death or major adverse cardiac events (MACE): retransplantation, non-fatal myocardial infarction, coronary revascularization, and heart failure hospitalization. RESULTS: One hundred and fifty-two heart transplant recipients (age, 54±15 years; 29% women; 5.0±5.4 years after heart transplantation) were included. Myocardial fibrosis was present in 18% (37% infarct pattern, 41% non-infarct pattern, and 22% both). Its prevalence was positively associated with cardiac allograft vasculopathy (CAV) grade. With a median follow-up of 2.6 years, myocardial fibrosis was independently associated with all-cause death or MACE (hazard ratio [HR], 2.88; 95% confidence interval [CI] 1.59–5.23; p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|