Y-chromosome polymorphisms and the origins of the European gene pool
Autor: | Casalotti R, Belledi M, Lucia Simoni, Guido Barbujani |
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Jazyk: | angličtina |
Rok vydání: | 1999 |
Předmět: |
Genetics
Mitochondrial DNA General Immunology and Microbiology Alu element General Medicine Biology Y chromosome General Biochemistry Genetics and Molecular Biology Article Gene flow Microsatellite Gene pool Restriction fragment length polymorphism General Agricultural and Biological Sciences Allele frequency General Environmental Science |
Popis: | Gradients of allele frequencies have long been considered the main genetic characteristic of the European population, but mitochondrial DNA diversity seems to be distributed differently. One Alu insertion (YAP), five tetranucleotide (DYS19, DYS389B, DYS390, DYS391 and DYS393) and one trinucleotide (DYS392) microsatellite loci of the Y chromosome were analysed for geographical patterns in 59 European populations. Spatial correlograms showed clines for most markers, which paralleled the gradients previously observed for two RFLP polymorphisms. Effective separation times between populations were estimated from genetic distances at microsatellite loci. Even after correcting for the possible effects of continuous local gene flow, the most distant Indo–European–speaking populations seem to have separated no more than 7000 years ago. The clinal patterns and the estimated, recent separation times between populations jointly suggest that Y–chromosome diversity in Europe largely reflects a directional demic expansion, which is unlikely to have occurred before the Neolithic period. |
Databáze: | OpenAIRE |
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