Treatment of aggressive adult T-cell leukemia/lymphoma: a retrospective study in a hospital located in HTLV-1 highly endemic area
| Autor: | Naosuke Arima, Tadashi Matsumoto, Kenji Ishitsuka, Makoto Yoshimitsu, Hirosaka Inoue, Kakushi Matsushita, Daisuke Nakamura, Naomichi Arima, Maiko Hayashida, Tomohisa Tabuchi |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Adult T-cell leukemia/lymphoma 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases Internal medicine medicine Neoplasm Humans Leukemia-Lymphoma Adult T-Cell Retrospective Studies Human T-lymphotropic virus 1 Hematology Deltaretrovirus Infections business.industry Endemic area Retrospective cohort study medicine.disease Hospitals Lymphoma stomatognathic diseases Leukemia Virus type 030220 oncology & carcinogenesis Disease Progression business 030215 immunology |
| Zdroj: | International journal of hematology. 111(2) |
| ISSN: | 1865-3774 |
| Popis: | Adult T-cell leukemia/lymphoma (ATL) is a peripheral T-cell neoplasm associated with the human T-cell leukemia virus type-I (HTLV-1); prognosis still remains very poor. We retrospectively reviewed the treatment of 198 patients with acute-, lymphoma- and unfavorable chronic-type ATL (aggressive ATL) diagnosed from 2005 to 2014 in a hospital located in an area of Japan in which HTLV-1 is highly endemic. One-hundred forty-three, and 35 patients were treated using OPEC/MPEC and VCAP-AMP-VECP, respectively. OPEC/MPEC was mainly used until around 2010, and gradually switched to VCAP-AMP-VECP, especially for younger patients. The 2-year overall survival for patients treated by VCAP-AMP-VECP was significantly higher than that using OPEC/MPEC for patients |
| Databáze: | OpenAIRE |
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