Reduced P300 amplitude is consistently associated with trait anhedonia across repeated assessments

Autor:	Nicholas J. Santopetro, Elizabeth M. Mulligan, Christopher J. Brush, Greg Hajcak
Rok vydání:	2022
Předmět:	Motivation Anhedonia Endocrine and Autonomic Systems Cognitive Neuroscience General Neuroscience Experimental and Cognitive Psychology Electroencephalography Event-Related Potentials P300 Neuropsychology and Physiological Psychology Developmental Neuroscience Neurology Humans Female Evoked Potentials Biological Psychiatry
Zdroj:	PsychophysiologyREFERENCES. 59(12)
ISSN:	1540-5958
Popis:	Understanding how event-related potentials (ERPs) change following repeated assessments is critical to advance our understanding of neural mechanisms implicated in psychopathology. Specifically, it is unclear if associations between ERPs and individual differences can be reproduced when repeatedly measured within the same participants, or if clinical characteristics impact ERP trajectories over repeated assessments. The present study assessed P300 amplitude and latency from a flanker task at four time points over one month (M = 7.24 days between assessments [SD = 1.02]) in 79 female undergraduates to examine how P300 amplitude/latency changes across repeated assessments, the presence of associations between within- and between-subjects measures of current depressive symptoms and the P300, and if between-subjects depressive symptoms moderated change in P300 over repeated assessment. Results using multilevel modeling indicated a significant reduction in P300 amplitude and latency across assessments. Individuals with increased trait anhedonia (i.e., between-subjects) exhibited reduced P300 amplitudes across assessments; there were no associations of within-subjects fluctuations in anhedonia symptoms and P300 amplitude across assessments. There was also no interaction between number of assessments and between-subjects anhedonia in relation to P300 amplitude. Unlike anhedonia, between-subjects dysphoria was unrelated to P300. These results demonstrate a relatively specific and consistent association between an attenuated P300 amplitude and trait anhedonia across repeated assessments - data that may further suggest that flanker P300 amplitude reflects hedonic and motivational processes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41d889ecc582cbc3c6bd8d7dbf57391c https://pubmed.ncbi.nlm.nih.gov/35775190 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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