Aerobic Exercise Prevents Insulin Resistance Through the Regulation of miR-492/Resistin Axis in Aortic Endothelium

Autor: Suixin Liu, Ying Cai, Kang-Ling Xie, Fan Zheng
Rok vydání: 2018
Předmět:
Blood Glucose
Male
0301 basic medicine
medicine.medical_specialty
Mice
Knockout
ApoE
Aortic Diseases
Regulator
Pharmaceutical Science
030204 cardiovascular system & hematology
03 medical and health sciences
0302 clinical medicine
Insulin resistance
Downregulation and upregulation
Internal medicine
Genetics
medicine
Animals
Aerobic exercise
Resistin
Aorta
Swimming
Genetics (clinical)
business.industry
nutritional and metabolic diseases
Lipid metabolism
Atherosclerosis
medicine.disease
Lipids
Plaque
Atherosclerotic
Exercise Therapy
Mice
Inbred C57BL
Disease Models
Animal
MicroRNAs
030104 developmental biology
Endocrinology
Gene Expression Regulation
Aortic endothelium
Molecular Medicine
Insulin Resistance
Cardiology and Cardiovascular Medicine
business
Biomarkers
hormones
hormone substitutes
and hormone antagonists
Signal Transduction
Zdroj: Journal of Cardiovascular Translational Research. 11:450-458
ISSN: 1937-5395
1937-5387
DOI: 10.1007/s12265-018-9828-7
Popis: Previously, we found that miR-492 delayed the progression of atherosclerosis (AS) by acting as an up-stream regulator of resistin. Therefore, we hypothesized that the anti-atherogenic effects of exercise are related to miR-492-mediated downregulation of resistin and repair of endothelial injury. In this study, we investigated the effects of the miR-492/resistin axis on improving endothelial injury in ApoE-/- mice (ApoE-deficient/knockout in C57BL/6 mice) through swimming exercises. Our results showed that the severity of AS and insulin resistance (IR) in these mice were significantly reduced by swimming exercises. In addition, miR-492 expression in the aortic endothelium of ApoE-/- mice was decreased, in addition to increased levels of resistin. Interestingly, swimming exercises increased miR-492 expression while decreasing that of resistin. Taken together, swimming exercises delayed the progression of AS, possibly by upregulating miR-492 and downregulating resistin in aortic endothelium. Therefore, exercises modulated glucose and lipid metabolism, alleviated endothelial IR, and repaired endothelial injury.
Databáze: OpenAIRE
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