Risk of non-medullary thyroid cancer influenced by polymorphic variation in the thyroglobulin gene
| Autor: | Clive Harmer, Sanjay Popat, Tania Kantemiroff, William D. Foulkes, Susan E.M. Clarke, Richard S. Houlston, Athena Matakidou, Nancy Hamel, Kiersten A. Henderson |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Oncology
endocrine system Cancer Research medicine.medical_specialty endocrine system diseases medicine.medical_treatment Population Thyroglobulin Gene Frequency Internal medicine Genotype medicine Humans Genetic Predisposition to Disease Thyroid Neoplasms education Thyroid cancer education.field_of_study Polymorphism Genetic business.industry Thyroid Medullary thyroid cancer General Medicine Odds ratio medicine.disease Confidence interval medicine.anatomical_structure Endocrinology business |
| Zdroj: | Carcinogenesis. 25:369-373 |
| ISSN: | 1460-2180 |
| DOI: | 10.1093/carcin/bgh027 |
| Popis: | Benign thyroid disorders are strong risk factors for nonmedullary thyroid cancer (NMTC). Germline variation in Tg (thyroglobulin) and TSHR (thyroid stimulating hormone receptor) confers an increased risk of benign thyroid disorders. To explore the hypothesis that polymorphic variation in these genes affects the risk of NMTC we compared the frequency of TgQ2511R, TSHR-P52T and TSHRD727E genotypes in two series of NMTC cases and controls (group 1, Canadian 102 cases and 102 controls; group 2, British 202 cases and 298 controls). No significant association was seen with TSHR-P52T and TSHR-D727E genotypes and risk of NMTC. However, the frequency of the R-allele of TgQ2511R was over represented in NMTC cases in both study populations. The odds ratios associated with hetero- and homozygosity for the R-allele were 1.6 (95% confidence interval, 1.1-- 2.5) and 2.0 (95% confidence interval, 1.2-- 3.3), respectively. Although the risk of NMTC associated with the TgQ2511R R-allele is modest, its high prevalence in the general population suggests it may make a significant contribution to the incidence of NMTC. |
| Databáze: | OpenAIRE |
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