Proteomic insights into an expanded cellular role for cytoplasmic lipid droplets
| Autor: | Brittany D. M. Hodges, Christine C. Wu |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Proteomics
Cytoplasm Phospholipid QD415-436 Biology adipose differentiation related protein Biochemistry chemistry.chemical_compound Endocrinology Lipid droplet Animals Humans Storage protein Cellular compartment mass spectrometry chemistry.chemical_classification Thematic Review Lipid metabolism Cell Biology Lipid Metabolism Lipids Cell biology protein sequestration PAT-family proteins chemistry adipophilin Function (biology) |
| Zdroj: | Journal of Lipid Research, Vol 51, Iss 2, Pp 262-273 (2010) |
| ISSN: | 0022-2275 |
| DOI: | 10.1194/jlr.r003582 |
| Popis: | Cytoplasmic lipid droplets (CLDs) are cellular structures composed of a neutral lipid core surrounded by a phospholipid monolayer of amphipathic lipids and a variety of proteins. CLDs have classically been regarded as cellular energy storage structures. However, recent proteomic studies reveal that, although many of the proteins found to associate with CLDs are connected to lipid metabolism, storage, and homeostasis, there are also proteins with no obvious connection to the classical function and typically associated with other cellular compartments. Such proteins are termed refugee proteins, and their presence suggests that CLDs may serve an expanded role as a dynamic protein storage site, providing a novel mechanism for the regulation of protein function and transport. |
| Databáze: | OpenAIRE |
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