Sucrose sham feeding decreases accumbens norepinephrine in the rat
| Autor: | Andras Hajnal, Ralph Norgren |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Male
Sucrose medicine.medical_specialty Microdialysis Time Factors Dopamine Administration Oral Experimental and Cognitive Psychology Stimulation Nucleus accumbens Nucleus Accumbens Rats Sprague-Dawley Norepinephrine Behavioral Neuroscience chemistry.chemical_compound Extended amygdala Internal medicine medicine Animals Neurotransmitter Chromatography High Pressure Liquid Analysis of Variance Behavior Animal Dose-Response Relationship Drug Chemistry Rats Sham feeding Endocrinology Catecholamine medicine.drug |
| Zdroj: | Physiology & Behavior. 82:43-47 |
| ISSN: | 0031-9384 |
| Popis: | Noradrenergic projections from the dorsomedial medulla reach the shell of the nucleus accumbens (NAcc), a structure implicated in both reward and feeding behavior. Despite this relationship, the effect of food reward on accumbens norepinephrine (NE) remains uninvestigated. In the course of assessing dopamine (DA) in the NAcc during sucrose ingestion [0.03, 0.1, and 0.3 M; Am. J. Physiol., Regul. Integr. Comp. Physiol. , 286 (2004) R31], we also analyzed NE in the microdialysis samples from 14 ad-libitum-fed male rats. In contrast to DA, which increased with sucrose concentration (+20–47%) during sham feeding, in the same animals, NE levels were reduced (approximately −20%), regardless of sucrose concentration. These results demonstrate a novel relationship between accumbens DA and NE during orosensory stimulation with a preferred nutrient. |
| Databáze: | OpenAIRE |
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