Red cell ferritin content: a re-evaluation of indices for iron deficiency in the anaemia of rheumatoid arthritis
| Autor: | M. J. Breidahl, Hubert Fong, M B Van der Weyden, Peter F J Ryan, Anne Davidson |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
musculoskeletal diseases
Adult Male medicine.medical_specialty Erythrocytes Adolescent Anemia Iron Gastroenterology Arthritis Rheumatoid Diagnosis Differential Internal medicine hemic and lymphatic diseases medicine Humans skin and connective tissue diseases Mean corpuscular volume General Environmental Science Aged Anemia Hypochromic biology medicine.diagnostic_test Red Cell business.industry Microcytosis General Engineering General Medicine Iron deficiency Middle Aged medicine.disease Ferritin Red blood cell medicine.anatomical_structure Rheumatoid arthritis Immunology Ferritins biology.protein General Earth and Planetary Sciences Female business Research Article |
| Zdroj: | British medical journal (Clinical research ed.). 289(6446) |
| ISSN: | 0267-0623 |
| Popis: | In iron deficiency anaemia basic red cell content of ferritin is appreciably reduced. This variable was determined in 62 patients with rheumatoid arthritis to evaluate conventional laboratory indices for iron deficiency in the anaemia of rheumatoid arthritis. For 23 patients with rheumatoid arthritis and normocytic anaemia irrespective of plasma ferritin concentration, red cell ferritin content did not differ significantly from that for non-anaemic patients with rheumatoid arthritis. For 27 patients with rheumatoid arthritis and microcytic anaemia, the mean red cell ferritin content for patients with a plasma ferritin concentration in the 13-110 micrograms/l range was appreciably reduced. It was indistinguishable from that for patients with rheumatoid arthritis and classical iron deficiency anaemia, indicated by plasma ferritin concentrations of less than 12 micrograms/l. In contrast, the mean red cell ferritin content for patients with rheumatoid arthritis, microcytic anaemia, and plasma ferritin concentrations above 110 micrograms/l did not differ from that for patients with rheumatoid arthritis and normocytic anaemia. Oral treatment with iron in patients with rheumatoid arthritis, microcytic anaemia, and appreciably reduced red cell ferritin concentrations was accompanied by significant increases in haemoglobin concentration (p less than 0.01), mean corpuscular volume (p less than 0.01), and red cell ferritin contents (p less than 0.05). This treatment, however, did not produce any appreciable change in haemoglobin concentration in patients with rheumatoid arthritis, normocytic anaemia, and normal red cell ferritin contents. These findings suggest that the indices for iron deficiency in patients with rheumatoid arthritis and anaemia should include peripheral blood microcytosis together with a plasma ferritin concentration of less than 110 micrograms/l. |
| Databáze: | OpenAIRE |
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