The Ah Receptor: Adaptive Metabolism, Ligand Diversity, and the Xenokine Model
| Autor: | Rachel H Wilson, Mark E. Hahn, Christopher A. Bradfield, Kristen Malecki, Mele N Avilla |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Polychlorinated Dibenzodioxins
Structural diversity Computational biology 010501 environmental sciences Biology Ligands Toxicology 01 natural sciences AH Receptor 03 medical and health sciences Animals Humans Polycyclic Aromatic Hydrocarbons Receptor 030304 developmental biology 0105 earth and related environmental sciences 0303 health sciences Molecular Structure Ligand Extramural General Medicine Metabolism Receptors Aryl Hydrocarbon Perspective Environmental Pollutants Signal transduction Receptor activation Signal Transduction |
| Zdroj: | Chemical Research in Toxicology |
| ISSN: | 1520-5010 0893-228X |
| Popis: | The Ah receptor (AHR) has been studied for almost five decades. Yet, we still have many important questions about its role in normal physiology and development. Moreover, we still do not fully understand how this protein mediates the adverse effects of a variety of environmental pollutants, such as the polycyclic aromatic hydrocarbons (PAHs), the chlorinated dibenzo-p-dioxins (“dioxins”), and many polyhalogenated biphenyls. To provide a platform for future research, we provide the historical underpinnings of our current state of knowledge about AHR signal transduction, identify a few areas of needed research, and then develop concepts such as adaptive metabolism, ligand structural diversity, and the importance of proligands in receptor activation. We finish with a discussion of the cognate physiological role of the AHR, our perspective on why this receptor is so highly conserved, and how we might think about its cognate ligands in the future. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|