Gene–physical activity interactions in lower extremity performance: inflammatory genes CRP, TNF-α, and LTA in community-dwelling elders

Autor:	Jen Hao Hsiao, Nai-Hsin Meng, Chih Hsueh Lin, Chuan Wei Yang, Fang Yang Wu, Li Na Liao, Cheng-Chieh Lin, Chiu-Shong Liu, Wen-Yuan Lin, Chia Ing Li, Tsai-Chung Li, Sung-Lin Hu
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	medicine.medical_specialty Genotype Science Taiwan Single-nucleotide polymorphism Polymorphism Single Nucleotide Article 03 medical and health sciences 0302 clinical medicine Polymorphism (computer science) Internal medicine Humans Medicine 030212 general & internal medicine Leg press Exercise Lymphotoxin-alpha Gene Inflammatory genes Multidisciplinary Tumor Necrosis Factor-alpha business.industry Preferred walking speed C-Reactive Protein Endocrinology Lower Extremity Physical therapy Tumor necrosis factor alpha Independent Living business Locomotion 030217 neurology & neurosurgery
Zdroj:	Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017) Scientific Reports
ISSN:	2045-2322
Popis:	We assessed gene–gene and gene-physical activity interactions of polymorphisms in C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), and lymphotoxin α (LTA) genes on lower extremity performance in community-dwelling elders in Taiwan. Five SNPs (rs1205, rs1130864, rs1800947, rs2794520, and rs3093059) of CRP gene, three SNPs (rs909253, rs1041981, and rs2239704) of LTA gene, and three SNPs (rs3093662, rs1800629, and rs1799964) of TNF-α gene of 472 unrelated elders were genotyped. Lower extremity performance included timed up-and-go test (TUG), walking speed, weight-adjusted leg press (waLP), and timed chair stand (TCS). We detected significant interactions between physical activity with CRP rs2794520, rs1205, and rs3093059; LTA rs909253 and rs1041981; and TNF-α rs1799964 for TCS in women after covariate adjustment (all P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41ce4ef4387933717b757c02a544f9b0 https://doaj.org/article/745ee0b5fb604b24b0cc479f56ed57e3 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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