Drug-like delivery methods of stem cells as biologics for stroke
| Autor: | Vanessa Castelli, Julian P. Tuazon, Cesar V. Borlongan |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Drug
media_common.quotation_subject medicine.medical_treatment Pharmaceutical Science Inflammation Translational research 02 engineering and technology Pharmacology 030226 pharmacology & pharmacy Article 03 medical and health sciences Delivery methods 0302 clinical medicine Animals Humans Medicine Secretion Stroke media_common Biological Products business.industry food and beverages Stem-cell therapy 021001 nanoscience & nanotechnology medicine.disease medicine.symptom Stem cell 0210 nano-technology business Stem Cell Transplantation |
| Zdroj: | Expert Opin Drug Deliv |
| ISSN: | 1744-7593 1742-5247 |
| DOI: | 10.1080/17425247.2019.1645116 |
| Popis: | INTRODUCTION: Stem cell therapy is an experimental treatment for brain disorders. Although a cellular product, stem cells can be classified as biologics based on the cells’ secretion of therapeutic substances. Treatment with stem cell biologics may appeal to stroke because of the secondary cell death mechanisms, especially neuroinflammation, that are rampant from the onset and remain elevated during the progressive phase of the disease requiring multi-pronged biological targets to effectively abrogate the neurodegenerative pathology. However, the optimal delivery methods, among other logistical approaches (i.e., cell doses and timing of intervention), for stem cell therapy will need to be refined before stem cell biologics can be successfully utilized for stroke in large scale clinical trials. AREAS COVERED: In this review, we discuss how the innate qualities of stem cells characterize them as biologics, how stem cell transplantation may be an ideal treatment for stroke, and the various routes of stem cell administration that have been employed in various preclinical and clinical investigations. EXPERT OPINION: There is a need to optimize the delivery of stem cell biologics for stroke in order to guide the safe and effective translation of this therapy from the laboratory to the clinic. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|