Long-Term Chronic Toxicity and Mesothelial Cell Reactions Induced by Potassium Octatitanate Fibers (TISMO) in the Left Thoracic Cavity in A/J Female Mice
| Autor: | Toshitaka Nakagawa, Masanao Yokohira, Nozomi Hashimoto, Sosuke Kishi, Fumiko Ninomiya, Katsumi Imaida, Yuko Nakano, Shohei Kanie, Keiko Yamakawa, Kousuke Saoo |
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| Rok vydání: | 2015 |
| Předmět: |
Mesothelioma
Pathology medicine.medical_specialty Lung Neoplasms Mice Inbred A Inflammation Spleen Thoracic Cavity Toxicology Kidney Mice medicine Animals Toxicity Tests Chronic Chronic toxicity Lung Titanium Thoracic cavity business.industry Mesothelioma Malignant Epithelial Cells Organ Size respiratory system medicine.disease respiratory tract diseases medicine.anatomical_structure Liver Pleura Female Bone marrow medicine.symptom business Mesothelial Cell |
| Zdroj: | International journal of toxicology. 34(4) |
| ISSN: | 1092-874X |
| Popis: | The present study was conducted to examine the chronic effects of potassium octatitanate fibers (trade name TISMO; chemical formula K2O·6TiO2) on the mouse lung and thoracic cavity. This method of infusion was employed to examine the direct effects of the fibers to the pleura. In the present study, 52- and 65-week experiments were employed to examine the long-term chronic effects after infusion of fiber-shaped TISMO into the thoracic cavities of A/J mice. Following this infusion, TISMO fibers were observed in the alveoli, indicating penetration through the visceral pleura. The additional histopathological detection of TISMO fibers in the liver, spleen, kidneys, ovary, heart, bone marrow, and brain of TISMO-infused mice indicated migration of the fibers out from the thoracic cavity. Atypical mesothelial cells with severe pleural proliferation were observed, but malignant mesotheliomas were not detected. This study demonstrated that intrathoracic infusion of TISMO fiber did not cause malignant mesothelioma but did cause severe chronic inflammation and proliferation of pleural mesothelial cells. |
| Databáze: | OpenAIRE |
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