Ocular allergy as a risk factor for dry eye in adults and children
| Autor: | Edoardo Villani, Paolo Nucci, Giovanni Rabbiolo |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
medicine.medical_specialty genetic structures Immunology MEDLINE Disease Pathogenesis 03 medical and health sciences 0302 clinical medicine Risk Factors Immunology and Allergy Medicine Humans Risk factor Child Conjunctivitis Allergic business.industry Dermatology eye diseases Ocular allergy 030228 respiratory system Tears 030221 ophthalmology & optometry Dry Eye Syndromes business |
| Zdroj: | Current opinion in allergy and clinical immunology. 18(5) |
| ISSN: | 1473-6322 |
| Popis: | To provide an overview of the pathogenic mechanisms underlying the correlation between ocular allergy and dry eye disease (DED), highlighting how the first condition may be a risk factor for the second one.Recent advances in our comprehension of the pathogenesis of ocular allergy and DED allow identifying several pathways of interaction between these two conditions. A growing body of evidence supports the role of ocular allergy as a risk factor for DED. Ocular allergy, particularly the severe forms of keratoconjunctivitis, can impact on different key mechanisms of the DED vicious cycle, including tear film instability, ocular surface inflammation and damage, and neurosensory abnormalities.Ocular allergy and DED are two common, relevant, symptomatic, not mutually exclusive conditions affecting the ocular surface. They share some clinical and biochemical features. To better understand the complex interactions between these two conditions, it's essential to consider the very wide spectrum of clinical conditions included in the term ocular allergy and the still largely unexplored peculiarities of the pediatric ocular surface physio-pathology and DED. |
| Databáze: | OpenAIRE |
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