Iridium-catalyzed enantioselective alkynylation and kinetic resolution of alkyl allylic alcohols

Autor:	Jia Guo, Hao-Ran Ma, Wen-Bin Xiong, Luoyi Fan, You-Yun Zhou, Henry N. C. Wong, Jian-Fang Cui
Rok vydání:	2022
Předmět:	General Chemistry
Zdroj:	Chemical Science. 13:13914-13921
ISSN:	2041-6539 2041-6520
DOI:	10.1039/d2sc04892b
Popis:	Herein, we report an efficient kinetic resolution of alkyl allylic alcohols enabled by an iridium-catalyzed enantioselective alkynylation of alkyl allylic alcohols with potassium alkynyltrifluoroborates. A wide range of chiral 1,4-enynes bearing various functional groups and unreacted enantioenriched allylic alcohols were obtained with excellent enantioselectivities and high kinetic resolution performance (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41ca311dfe81dc803bbfccb22ae2d55a https://doi.org/10.1039/d2sc04892b Zobrazit plný text záznamu