ASSESSMENT OF CLINICAL MEANINGFULNESS OF ENDPOINTS IN THE GENERATION PROGRAM BY THE INSIGHTS TO MODEL ALZHEIMER’S PROGRESSION IN REAL LIFE (IMAP) STUDY
| Autor: | Anders Gustavsson, Jessica B. Langbaum, Vissia Viglietta, Vladimir Bezlyak, Pierre N. Tariot, C. Lopez Lopez, Ana Graf, Angelika Caputo, V Risson |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
Gerontology Repeatable Battery for the Assessment of Neuropsychological Status medicine.medical_specialty Neurology Clinical Dementia Rating Apolipoprotein E4 Disease Neuropsychological Tests Alzheimer Disease Activities of Daily Living Outcome Assessment Health Care Humans Medicine Dementia Cognitive Dysfunction Longitudinal Studies Prospective Studies Aged Proportional Hazards Models Aged 80 and over business.industry Cognition Middle Aged Mental Status and Dementia Tests medicine.disease Cognitive test Case-Control Studies Disease Progression Quality of Life Female business Cohort study |
| Zdroj: | The Journal Of Prevention of Alzheimer's Disease. :1-5 |
| ISSN: | 2274-5807 |
| DOI: | 10.14283/jpad.2018.49 |
| Popis: | We are launching the Insights to Model Alzheimer’s Progression in Real Life study in parallel with the Alzheimer Prevention Initiative Generation Program. This is a 5-year, multinational, prospective, longitudinal, non-interventional cohort study that will collect data across the spectrum of Alzheimer’s disease. The primary objective is to assess the ability of the Alzheimer’s Prevention Initiative Cognitive Composite Test Score and Repeatable Battery for the Assessment of Neuropsychological Status to predict clinically meaningful outcomes such as diagnosis of mild cognitive impairment or dementia due to Alzheimer’s disease, and change in Clinical Dementia Rating – Global Score. This study is the first large-scale, prospective effort to establish the clinical meaningfulness of cognitive test scores that track longitudinal decline in preclinical Alzheimer’s disease. This study is also expected to contribute to our understanding of the relationships among outcomes in different stages of Alzheimer’s disease as well as models of individual trajectories during the course of the disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink