A Rapid and Efficient Synthesis of 2-Butyl-5-chloro-3H-imidazole-4-carboxaldehyde

Autor:	K. Srinivas, M. Pardhasaradhi, S. Ramesh, C. K. Snehalatha Nair
Rok vydání:	2004
Předmět:	chemistry.chemical_compound Nitrile Chemistry Organic Chemistry Imidazole Organic chemistry Tetrazole General Medicine Imidazole-4-carboxaldehyde Combinatorial chemistry High-performance liquid chromatography Catalysis
Zdroj:	ChemInform. 35
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200428141
Popis:	A rapid, efficient, cost effective procedure has been developed for the synthesis of 2-hutyl-5-chloro-3H-imidazole-4-carboxaldehyde. Preparation of methyl pentanimidate was accomplished in just 12 hours, followed by a sequence of reactions without isolation and purification of the formed intermediates. The final compound was purified by simple acid-base treatment to get a product with 99.9% HPLC purity.
Databáze:	OpenAIRE
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