Prediction of fetal lung and kidney maturity by determination of amniotic fluid lecithin: sphingomyelin ratio and creatinine concentration
| Autor: | R D Paton, R W Logan, John MacVicar |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
medicine.medical_specialty
Amniotic fluid Pregnancy in Diabetics Gestational Age 030204 cardiovascular system & hematology Kidney Andrology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Fetus Pre-Eclampsia Pregnancy Internal medicine medicine Humans 030212 general & internal medicine Lung Creatinine Clinical Trials as Topic Respiratory Distress Syndrome Newborn medicine.diagnostic_test business.industry Body Weight Infant Newborn Gestational age General Medicine medicine.disease Amniotic Fluid Sphingomyelins Endocrinology medicine.anatomical_structure chemistry Amniocentesis Phosphatidylcholines Female business |
| Zdroj: | Scottish medical journal. 19(5) |
| ISSN: | 0036-9330 |
| Popis: | The ratio of lecithin to sphingomyelin (L/S) in amniotic fluid was assessed in 209 patients on 275 occasions and confirmed to be a useful index of fetal lung maturity.Although low and high ratios were found mainly at early and late gestational ages respectively, lung maturity (L/S ratio ≥ 3:1) occurred at a wide range of ages, from 28 to 40 weeks. The L/S ratio was, therefore, not found to be a useful index of gestational age in individual cases.In 174 cases, in addition to determining the L/S ratio, the concentration of creatinine in the liquor was estimated as an index of renal maturity. (Creatinine ≥ 1.6 mg./100 ml. ≡ renal maturity). In 80 per cent of cases, lung and kidney were judged to be both mature or both immature. In the remainder, combinations of mature kidney/immature lung or immature kidney/mature lung existed. Liquor creatinine estimation remains useful as a guide to gestational age and as an adjunct to lung maturity studies. |
| Databáze: | OpenAIRE |
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