| Autor: |
Anna C. Everett, Ben E. Graul, Joakim W. Ronström, J. Kayden Robinson, Daniel B. Watts, Rodrigo A. España, Cody A. Siciliano, Jordan T. Yorgason |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
ACS chemical neuroscience. 13(10) |
| ISSN: |
1948-7193 |
| Popis: |
Fast-scan cyclic voltammetry (FSCV) is an effective tool for measuring dopamine release and clearance throughout the brain, especially the striatum where dopamine terminals are abundant and signals are heavily regulated by release machinery and the dopamine transporter (DAT). Peak height measurement is perhaps the most common method for measuring dopamine release, but it is influenced by changes in clearance. Michaelis-Menten-based modeling has been a standard in measuring dopamine clearance, but it is problematic in that it requires experimenter fitted modeling subject to experimenter bias. This study presents the use of the first derivative (velocity) of evoked dopamine signals as an alternative approach for measuring and distinguishing dopamine release from clearance. Maximal upward velocity predicts reductions in dopamine peak height due to D |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
