Effects of ACE inhibition on renal haemodynamics in essential hypertension and hypertension associated with chronic renal failure
| Autor: | Marcó Ej, Gilbert Bh, C A Traballi, Agustin J. Ramirez, G Long, Ramiro A. Sanchez |
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| Rok vydání: | 1991 |
| Předmět: |
Adult
Male medicine.medical_specialty Hypertension Renal Adolescent Angiotensin-Converting Enzyme Inhibitors Blood Pressure urologic and male genital diseases Essential hypertension Kidney Renal Circulation Enalapril Internal medicine Medicine Humans Pharmacology (medical) Renal sodium reabsorption biology business.industry Angiotensin-converting enzyme Cilazapril Middle Aged medicine.disease Angiotensin II Filtration fraction Pyridazines medicine.anatomical_structure Endocrinology Pathophysiology of hypertension Renal blood flow Hypertension biology.protein Kidney Failure Chronic Female business |
| Zdroj: | Drugs. 41 |
| ISSN: | 0012-6667 |
| Popis: | Angiotensin II has many actions in the kidney, including regulation and distribution of renal circulation and glomerular filtration, as well as effects on mesangial contraction and on the filtration coefficient. The reduction in circulating and intrarenal angiotensin II by angiotensin converting enzyme (ACE) inhibitors in essential hypertension is associated with a significant increase in renal blood flow and a decrease in filtration fraction, without changes in glomerular filtration rate. In addition, administration of ACE inhibitors can reduce proximal sodium reabsorption via changes in peritubular hydrostatic and oncotic forces resulting from the fall in postglomerular capillary resistance. In severe hypertension the state of the renal vasculature does not allow ACE inhibition to induce similar haemodynamic changes and, therefore, it cannot contribute to renal sodium handling that requires the recruitment of alternate mechanisms. In spite of this, ACE inhibitors may exert a protective effect on the renal function of patients with severe hypertension as well as in those with renal impairment, by lowering systemic and, probably, intraglomerular pressure, reducing proteinuria and slowing the progression of renal failure. |
| Databáze: | OpenAIRE |
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