Lipolytic action of EDTA and catechol amines in intact and homogenized adipose tissue
| Autor: | B. Mosinger |
|---|---|
| Rok vydání: | 1969 |
| Předmět: |
Male
medicine.medical_specialty Molar concentration Epinephrine Adipose tissue chemistry.chemical_element Fatty Acids Nonesterified In Vitro Techniques Calcium Imides General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Internal medicine medicine Animals Lipolysis Magnesium General Pharmacology Toxicology and Pharmaceutics Edetic Acid Chelating Agents Epididymis Catechol General Medicine Rats EGTA Endocrinology Adipose Tissue chemistry Ethers medicine.drug |
| Zdroj: | Life Sciences. 8:137-146 |
| ISSN: | 0024-3205 |
| Popis: | EDTA in 5 mM concentration stimulated lipolysis in intact adipose tissue fragments while EGTA was without effect under similar conditions. EDTA did not change the effect of simultaneously added high concentration of epinephrine (5 ug per ml) and potentiated its effect when used in low concentration (0.2 ug per ml). EDTA action on intact adipose tissue was blocked by the same molar concentration of calcium and magnesium. EDTA as well as norephinephrine in two-step procedure were able to stimulate lipolysis in adipose tissue homogenate. This effect, however, could not be neutralized by equimolar concentrations of calcium and magnesium. Higher concentration of calcium and magnesium inhibited the lipolysis and its activation by epinephrine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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