Efficacy and tolerability of multiple drug therapy in HIV-infected children
| Autor: | Roberta Bianchi, Alessandra Viganò, Stefano Rusconi, Laura Schneider, Mirko Lo Cicero, Vania Giacomet, Elisabetta Bulgheroni, Francesca Soster |
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| Rok vydání: | 2004 |
| Předmět: |
Microbiology (medical)
Male medicine.medical_specialty Adolescent Gastrointestinal Diseases HIV Infections Pharmacotherapy Acquired immunodeficiency syndrome (AIDS) Internal medicine Antiretroviral Therapy Highly Active medicine Humans Adverse effect Sida Child Hepatitis Acquired Immunodeficiency Syndrome biology business.industry Viral Load medicine.disease biology.organism_classification Surgery CD4 Lymphocyte Count Infectious Diseases Treatment Outcome Tolerability Anti-Retroviral Agents Pancreatitis HIV-1 RNA Viral Drug Therapy Combination Female Viral disease business |
| Zdroj: | The Journal of infection. 50(5) |
| ISSN: | 0163-4453 |
| Popis: | To characterize the efficacy and tolerability of multiple drug therapy (MDT) among heavily pre-treated HIV-infected children.An observational study of seven children treated with 4-7 antiretroviral agents. MDT regimens were chosen with regard to past antiretroviral exposure and genotypic resistance data. Five children received MDT once, one child twice and one child four times. All patients had AIDS and severe CD4+ depletion and failed2 PI-based HAART regimens.Virologic response, defined as aor =log10 decrease in plasma HIV-1 RNA at week 24, was achieved in 7/11 MDT. Successful MDT kept a sustained viral suppression (50 copies/ml) at longest follow-up (72-96 weeks). Successful MDT obtained a great immune recovery: the median rise in absolute and percentage of CD4+ cells was 261 and 4 at week 24 and it reached 480 and 16 at 72-96 weeks. Adverse events were common but generally manageable. Mild/moderate gastrointestinal complaints and laboratory abnormalities were detected in 5/11 and 8/11 MDT. Grade 2 severity pancreatitis occurred in one case with chronic active hepatitis C. Pancreatitis resolved within 30 days of MDT interruption.MDT may be a therapeutic option in children who failed to respond to most standard HAART regimens. |
| Databáze: | OpenAIRE |
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