Prevalence and correlates of Benign Pancreatic Hyperenzymemia in a large general population sample: The Damocles sword perception
| Autor: | Carolina Ciacci, Fabiana Zingone, Luna Carpinelli, Mario De Santis, Pierpaolo Cavallo, Immacolata Sepe |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Pancreatic disease Adolescent Population sample Epidemiology Endocrinology Diabetes and Metabolism Population Disease Reference laboratory General practitioner Young Adult Endocrinology Benign hyperenzymemia Internal medicine Prevalence medicine Humans Electronic health records Child education Pancreas Aged Retrospective Studies education.field_of_study Hepatology business.industry Gastroenterology Infant Pancreatic Diseases General population Pancreatic enzyme Retrospective cohort study Middle Aged medicine.disease Diabetes and Metabolism Cross-Sectional Studies Italy Child Preschool Female business Pancreatic enzymes |
| Zdroj: | Pancreatology (Online) 19 (2019): 409–413. doi:10.1016/j.pan.2019.03.003 info:cnr-pdr/source/autori:Cavallo P.; Carpinelli L.; Zingone F.; Sepe I.; De Santis M.; Ciacci C./titolo:Prevalence and correlates of Benign Pancreatic Hyperenzymemia in a large general population sample: The Damocles sword perception/doi:10.1016%2Fj.pan.2019.03.003/rivista:Pancreatology (Online)/anno:2019/pagina_da:409/pagina_a:413/intervallo_pagine:409–413/volume:19 |
| DOI: | 10.1016/j.pan.2019.03.003 |
| Popis: | Background Benign Pancreatic Hyperenzymemia (BPH) is characterized by a long-term increase of serum pancreatic enzymes (PE) in otherwise healthy subjects. The study investigates the prevalence and correlates of the condition using data from Electronic Health Records (EHR) in a large sample of general population, to identify subjects potentially affected by BPH. Methods Cross-sectional retrospective observational study integrated by a follow-up visit. Results The database of a reference laboratory identified, out of 577.251 admittances from 2011 to 2015, 4964 patients tested at least for one PE assay and 1688 subjects who had at least 3 PE tests (normal or increased) over two years. Forty-two individuals showed an increase of PE at least three times throughout 2 years without any evidence of pancreatic disease, even after matching with the ICD 9-CM code in the GPs database. Data retrieved at follow-up visit showed that for 34 the diagnosis of BPH could be made. Conclusions Our data indicate that BPH prevalence among subjects underwent blood testing for multiple PE testing is 2%. This condition, even if not a disease, is perceived by nearly all the BPH patients as a serious threat to their life. Further studies are needed to manage its heavy psychological impact. |
| Databáze: | OpenAIRE |
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