Comorbidities, timing of treatments, and chemotherapy use influence outcomes in stage III colon cancer: A population-based European study

Autor:	Fortunato Bianconi, V. Babaev, A. Mateos, E. Almar, E. Fournier, Rafael Marcos-Gragera, Katrijn Vanschoenbeek, C. Alberich, Maria José Bento, Valérie Jooste, MaCarmen Carmona-Garcia, Eva Ardanaz, Alexander Katalinic, Paolo Giorgi Rossi, Liesbet Van Eycken, Christine Bouchardy, G. Carrozzi, G. Launoy, Clara Castro, Elisabetta Rapiti, R. Tumino, K. Jarm, C. Castro, Pamela Minicozzi, Laufey Tryggvadottir, Marcela Guevara, Véronique Bouvier, Claudia Cirilli, C. Amati, Milena Sant, M. Sant, T. Grozeva, A.I. Marcos Navarro, P. Baili, Ana Miranda, M. Oko, P. Giorgi Rossi, M. Vicentini, Fabrizio Stracci, Giovanna Tagliabue, R. Jiménez Chillarón, M. Primic Žakelj, Magdalena Bielska-Lasota, G. Moretti, M-J Sanchez, K. Innos, M. Robaszkiewicz, L. Van Eycken, M. Guevara, J. Faivre, Kaire Innos, M. Bielska-Lasota, P. Macek, A. Katalinic, W. Kycler, E. Meneghini, E.J. Ólafsdóttir, F. Stracci, M. de la Cruz, María José Sánchez, J. Bidaurrazaga, Zdravka Valerianova, Sébastien Normand, R. Marcos-Gragera, A. Mayer-da-Silva, J. Smok-Kalwat, M. Rodriguez-Barranco, M.C. Carmona-Garcia, Ana Torrella-Ramos, Margit Mägi, P. Minicozzi, Massimo Vicentini, K. Henau, Anne Marie Bouvier, E. Spata, S. Bonfarnuzzo, Miguel Rodríguez-Barranco, Paolo Contiero
Přispěvatelé:	Instituto de Saúde Pública da Universidade do Porto, Fournier, Evelyne, Bouchardy Magnin, Christine
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Adult Male medicine.medical_specialty Adolescent medicine.medical_treatment Population Antineoplastic Agents Comorbidity Population based Outcomes Time-to-Treatment Comorbidities Young Adult 03 medical and health sciences 0302 clinical medicine Standard treatment medicine Humans 030212 general & internal medicine Elective surgery Stage (cooking) education Aged Neoplasm Staging Retrospective Studies ddc:613 Population-based study Aged 80 and over education.field_of_study Chemotherapy business.industry General Medicine Middle Aged Prognosis Combined Modality Therapy Surgery Stage III Colon Cancer Europe Survival Rate Oncology Population Surveillance 030220 oncology & carcinogenesis Charlson comorbidity index Colonic Neoplasms Female Stage III colon cancer business
Zdroj:	European Journal of Surgical Oncology (2020)
ISSN:	0748-7983
Popis:	Introduction For stage III colon cancer (CC), surgery followed by chemotherapy is the main curative approach, although optimum times between diagnosis and surgery, and surgery and chemotherapy, have not been established. Materials and methods We analysed a population-based sample of 1912 stage III CC cases diagnosed in eight European countries in 2009–2013 aiming to estimate: (i) odds of receiving postoperative chemotherapy, overall and within eight weeks of surgery; (ii) risks of death/relapse, according to treatment, Charlson Comorbidity Index, time from diagnosis to surgery for emergency and elective cases, and time from surgery to chemotherapy; and (iii) time-trends in chemotherapy use. Results Overall, 97% of cases received surgery and 65% postoperative chemotherapy, with 71% of these receiving chemotherapy within eight weeks of surgery. Risks of death and relapse were higher for cases starting chemotherapy with delay, but better than for cases not given chemotherapy. Fewer patients with high comorbidities received chemotherapy than those with low (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41b705fc8f94269f35baaf8ea8845a2d http://hdl.handle.net/11391/1461762 Zobrazit plný text záznamu Full Text from ScienceDirect