Improved classification of rheumatoid arthritis with a score including anti-acetylated ornithine antibodies
| Autor: | Alejandro Balsa, Ana M. Ortiz, Laura Nuño, Cristina Regueiro, Ana Martínez-Feito, Diana Peiteado, Ana Triguero-Martinez, Isidoro González-Álvaro, Alejandro Villalba, Holger Bang, L Rodriguez-Martinez, Antonio Gonzalez |
|---|---|
| Přispěvatelé: | UAM. Departamento de Medicina, Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Male Ornithine rheumatoid arthritis medicine.medical_specialty Medicina Concordance lcsh:Medicine Antibody level Gastroenterology Peptides Cyclic Article Arthritis Rheumatoid 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Rheumatic diseases Rheumatology Internal medicine Medicine Rheumatoid factor Humans antibodies Rheumatoid arthritis lcsh:Science Aged Autoantibodies 030203 arthritis & rheumatology Multidisciplinary anti‑acetylated ornithine biology business.industry lcsh:R Autoantibody Middle Aged medicine.disease 030104 developmental biology chemistry biology.protein classification criteria Female lcsh:Q Antibody business Early arthritis |
| Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020) Biblos-e Archivo. Repositorio Institucional de la UAM instname Scientific Reports Biblos-e Archivo: Repositorio Institucional de la UAM Universidad Autónoma de Madrid |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-020-73919-y |
| Popis: | The presence of rheumatoid factor (RF) or anti-cyclic citrullinated peptide (anti-CCP) autoantibodies contributes to the current rheumatoid arthritis (RA) classification criteria. These criteria involve stratification on antibody levels, which limits reproducibility, and underperform in the RA patients without RF and anti-CCP. Here, we have explored if two anti-acetylated peptide antibodies (AAPA), anti-acetylated lysine (AcLys) and anti-acetylated ornithine (AcOrn), could improve the performance of the current criteria. The analysis was done in 1062 prospectively-followed early arthritis (EA) patients. The anti-AcOrn were more informative than the anti-AcLys, the conventional RA antibodies and the anti-carbamylated protein antibodies. The anti-AcOrn produced a classification that did not require antibody levels and showed improved specificity (77.6% vs. 72.6%, p = 0.003) and accuracy (79.0% vs. 75.8%, p = 0.002) over the current criteria. These improvements were obtained with a scoring system that values concordance between anti-AcOrn, RF and anti-CCP. No significant gain was obtained in sensitivity (80.2% vs. 78.8%, p = 0.25) or in improving the classification of the RA patients lacking RF and anti-CCP, although the anti-AcOrn ranked first among the analysed new antibodies. Therefore, the anti-AcOrn antibodies could contribute to the improvement of RA classification criteria by exploiting antibody concordance. This work was supported by the Instituto de Salud Carlos III (Spain) through grants [RD16/0012/0014 and PI17/01606 to AG; RD16/0012/0012 to AB; PI14/00442 and RD16/0012/0011 to IG-A]. These grants are partially financed by the European Regional Development Fund of the EU (FEDER). LRM was supported by Xunta de Galicia (Spain) through a Gain pre-doctoral fellowship. CR was supported by Ministerio de Educacion Cultura y Deporte (Spain) through a FPU pre-doctoral fellowship [FPU15/03434]. |
| Databáze: | OpenAIRE |
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