Screening for illegal addition of glucocorticoids in adulterated cosmetic products using ultra-performance liquid chromatography/tandem mass spectrometry with precursor ion scanning
| Autor: | Han Jing, Ke Wang, Longhai Jian, Yuan Xiaoqian, Rong Zheng, Peng Xingsheng |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
endocrine system
media_common.quotation_subject Cosmetics Tandem mass spectrometry 01 natural sciences High-performance liquid chromatography Analytical Chemistry Liquid chromatography–mass spectrometry Limit of Detection Tandem Mass Spectrometry polycyclic compounds Screening method Humans Glucocorticoids Spectroscopy Chromatography High Pressure Liquid media_common Detection limit Chromatography Chemistry 010401 analytical chemistry Organic Chemistry 0104 chemical sciences Consumer Product Safety sense organs Drug Contamination hormones hormone substitutes and hormone antagonists |
| Zdroj: | Rapid communications in mass spectrometry : RCMREFERENCES. 35(3) |
| ISSN: | 1097-0231 |
| Popis: | RATIONALE The screening for illegal adulteration of glucocorticoids (GCs) in cosmetics is challenging due to the vast variety of potential GCs that are present to improve the declared effects. An effective analytical method to screen illegally added GCs in cosmetics is vital to protect consumers. METHODS An ultra-performance liquid chromatography/tandem mass spectrometry (UPLC/MS/MS) method using precursor ion scanning (PIS) acquisition mode was developed to screen GCs in cosmetics. Forty-seven GCs were investigated to identify their common product ions formed by collision-induced dissociation. Cosmetic samples spiked with GCs were extracted using solid-phase extraction. RESULTS Four common positive product ions, m/z 121, 135, 147, and 171, were selected for PIS analysis. Limits of detection (LODs) were established for all 47 GCs. The method was validated on spiked samples to ensure its effectiveness in terms of sensitivity and selectivity. Sixty samples were analyzed. Seven GCs were detected in six samples. CONCLUSIONS An effective screening method using UPLC/MS/MS with PIS acquisition mode was developed and successfully applied to screen for targeted and untargeted GCs in cosmetic samples. |
| Databáze: | OpenAIRE |
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