Combining Wire Localization of Clipped Nodes with Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy in Node-Positive Breast Cancer: Preliminary Results from a Prospective Study

Autor: José Ramón Varela, Carmen Conde, Paz Santiago Freijanes, Joaquín Mosquera Oses, Lourdes Calvo Martínez, Alberto Bouzón Alejandro, Carlota Czestokowa Díaz Carballada, Inma Díaz, Silvia Antolín Novoa, Benigno Acea-Nebril, Sofia Rodríguez Martínez, Alejandra García-Novoa, Carmen Cereijo Garea
Rok vydání: 2020
Předmět:
Zdroj: Annals of Surgical Oncology. 28:958-967
ISSN: 1534-4681
1068-9265
DOI: 10.1245/s10434-020-08925-5
Popis: The ideal technique for lymph node staging for patients with pathologically confirmed node-positive breast cancer at diagnosis and neoadjuvant chemotherapy (NAC) is unclear. The aim of this study was to analyze the feasibility of wire/clip localization and sentinel lymph node biopsy (SLNB) for the axillary staging of these patients. We conducted a prospective study in which lymph node staging was performed using wire localization of positive lymph nodes and an SLNB with dual tracer. All patients who presented no metastatic involvement of the sentinel lymph node (SLN) or clip/wire-marked lymph node were spared an axillary lymph node dissection (ALND). The multidisciplinary committee agreed on axillary treatment for patients with lymph node involvement. Forty-two patients met the inclusion criteria. We identified and extirpated the clip/wire-marked node in all patients (100%), with SLNB performed successfully in 95.3% of patients. The SLN and wire-marked node matched in 80% of patients; 73.8% of patients did not undergo ALND. Several studies have evaluated the efficacy of various procedures for lymph node marking for women with prechemotherapy lymph node involvement. Most of the studies reported high identification rates (> 94.8%), with false negative rates of
Databáze: OpenAIRE
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