Bisphenol A affects vipergic nervous structures in the porcine urinary bladder trigone
| Autor: | Krystyna Makowska, Andrzej Rychlik, Sławomir Gonkowski, Mariusz Majewski, Piotr Lech |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Bisphenol A endocrine system Swine Science Vasoactive intestinal peptide Urinary Bladder Neurophysiology Air Pollutants Occupational Cellular imaging Article Enteric Nervous System Urinary Bladder Trigone Environmental impact chemistry.chemical_compound Nerve Fibers Phenols Internal medicine medicine Animals Benzhydryl Compounds Neurons Multidisciplinary Urinary bladder Chemistry urogenital system medicine.anatomical_structure Endocrinology Endocrine disruptor Distribution pattern Medicine Female hormones hormone substitutes and hormone antagonists Vasoactive Intestinal Peptide |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) |
| ISSN: | 2045-2322 |
| Popis: | Bisphenol A (BPA) is used in the production of plastics approved for contact with feed and food. Upon entering living organisms, BPA, as a potent endocrine disruptor, negatively affects various internal organs and regulatory systems, especially in young individuals. Although previous studies have described the neurotoxic effects of BPA on various tissues, it should be underlined that the putative influence of this substance on the chemical architecture of the urinary bladder intrinsic innervation has not yet been studied. One of the most important neuronal substances involved in the regulation of urinary bladder functions is vasoactive intestinal polypeptide (VIP), which primarily participates in the regulation of muscular activity and blood flow. Therefore, this study aimed to determine the influence of various doses of BPA on the distribution pattern of VIP-positive neural structures located in the wall of the porcine urinary bladder trigone using the double-immunofluorescence method. The obtained results show that BPA influence leads to an increase in the number of both neurons and nerve fibres containing VIP in the porcine urinary bladder trigone. This may indicate that VIP participates in adaptive processes of the urinary bladder evoked by BPA. |
| Databáze: | OpenAIRE |
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