Antinociceptive effect and acute toxicity of the Hyptis suaveolens leaves aqueous extract on mice
| Autor: | Thiago C. Santos, Sócrates Cabral de Holanda Cavalcanti, Ana C. S. Carvalho, Kellyane S. Dias, Igor A. C. Menezes, Aline B. L. Silva, Rosilene M. Marçal, Iderjane C.M. Mello, Maxsuel S. Marques, Angelo R. Antoniolli |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Hot Temperature Administration Oral Pain Pharmacognosy Mice Acetic acid chemistry.chemical_compound Oral administration Drug Discovery Hyptis suaveolens Animals Medicine Acetic Acid Pharmacology Analgesics Dose-Response Relationship Drug Traditional medicine biology Plant Extracts business.industry General Medicine biology.organism_classification Acute toxicity Plant Leaves Nociception chemistry Toxicity Female Hyptis business Licking Phytotherapy |
| Zdroj: | Fitoterapia. 78:333-336 |
| ISSN: | 0367-326X |
| Popis: | The aqueous extract of Hyptis suaveolens leaves was studied for their antinociceptive property in chemical and thermal models of nociception in mice. Oral administration of the aqueous extract (100, 200, and 400 mg/kg) dose-dependently reduced the number of writhings induced by acetic acid, decreased the licking activity of the early phase in formalin test and increased the reaction time in hot-plate test. The antinociceptive effect was significantly antagonized by naloxone (3 mg/kg; i.p.). Preliminary acute toxicity study showed that no animal death with doses up to 5 g/kg (p.o.). |
| Databáze: | OpenAIRE |
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