Methotrexate-induced pulmonary toxicity in psoriatic arthritis (PsA): case presentation and literature review
| Autor: | Federico Rondón, Edgar Penaranda, Luis R. Espinoza, Ignacio Garcia-Valladares, Nestor Spinel, Carlos Darío Ochoa, Cristian Saavedra, Odilio Méndez, Antonio Iglesias-Gamarra |
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| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Pulmonary toxicity Pulmonary Fibrosis Arthritis Lung injury Gastroenterology Psoriatic arthritis Fatal Outcome Rheumatology Internal medicine Pulmonary fibrosis medicine Humans business.industry Arthritis Psoriatic General Medicine Middle Aged medicine.disease Surgery Methotrexate Methylprednisolone Antirheumatic Agents Acute Disease Female business medicine.drug |
| Zdroj: | Clinical rheumatology. 30(10) |
| ISSN: | 1434-9949 |
| Popis: | A 45-year-old female with a 4-week history of psoriatic arthritis developed cough, fever, and progressive shortness of breath 2 weeks following initiation of methotrexate therapy. High resolution CT of chest revealed bilateral basal interstitial involvement and diffuse ground glass opacities. Patient, though, died despite immediate discontinuation of methotrexate and initiation of treatment with IV methylprednisolone and cyclophosphamide. Post-mortem examination showed diffuse interstitial pulmonary fibrosis. Methotrexate-induced pulmonary toxicity is a serious event, unpredictable, and unusual, especially in patients with psoriatic arthritis, and although reversible, it may be fatal. |
| Databáze: | OpenAIRE |
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