Combination therapy with lentinan improves outcomes in patients with esophageal carcinoma
| Autor: | Zheng Bi, Xiao-Meng Gu, Ji-Lian Wang, Jian-Wen Zou |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Oncology
Adult Male Cancer Research medicine.medical_specialty Combination therapy Esophageal Neoplasms medicine.medical_treatment Lentinan Antineoplastic Agents Biochemistry Gastroenterology Tegafur chemistry.chemical_compound Pharmacotherapy Quality of life Internal medicine Genetics medicine Carcinoma Humans Molecular Biology Aged Chemotherapy business.industry Interleukin-6 Middle Aged medicine.disease Chemotherapy regimen Interleukin-12 Interleukin-10 Treatment Outcome chemistry Molecular Medicine Cytokines Interleukin-2 Drug Therapy Combination Female Interleukin-4 business medicine.drug |
| Zdroj: | Molecular medicine reports. 5(3) |
| ISSN: | 1791-3004 |
| Popis: | With a view to improving treatment response and the quality of life of cancer patients, this study investigated the clinical efficacy of combining lentinan, a flavonoid compound with antitumor abilities, with traditional chemotherapy in individuals with esophageal carcinoma (EC), with a particular focus on its effect on immune function. A total of 50 patients undergoing treatment for EC were evenly divided into two groups: control and experimental. Patients in the control group were treated with the chemotherapeutic agent tegafur (1,000 mg/day for 5 days); patients in the experimental group were treated with the same dosage of tegafur combined with 1 mg lentinan diluted in 250 ml normal saline. Patients were monitored for their general condition, symptoms and signs, quality of life and clinical efficacy (remission vs. progression). Additionally, the effects of lentinan on immune function were assessed through analysis of serum levels of pro-inflammatory and anti-inflammatory cytokines using enzyme-linked immunosorbent assay (ELISA) prior to and following the first and second course of treatment. The results of the scores showed that the general condition (Karnofsky performance scale; KPS), the symptoms and signs (Zubrod-ECOG-WHO score; ZPS) and the quality of life (QOL scale) of the patients following the first and second course of treatment were better in both groups compared to the scores prior to treatment; however, patients in the experimental group exhibited significantly greater improvement than those in the control group (P |
| Databáze: | OpenAIRE |
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