Regulatory Role of Small Nucleolar RNAs in Human Diseases
| Autor: | Julia A. Filippova, Dmitry V. Semenov, Elena V. Kuligina, Vladimir A. Richter, G. A. Stepanov, Andrey Komissarov |
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| Rok vydání: | 2015 |
| Předmět: |
lcsh:Medicine
Review Article Biology General Biochemistry Genetics and Molecular Biology Blood serum Stress Physiological Neoplasms Animals Humans RNA Small Nucleolar Disease RNA Neoplasm RNA Processing Post-Transcriptional Small nucleolar RNA Regulation of gene expression Genetics Messenger RNA General Immunology and Microbiology urogenital system lcsh:R Alternative splicing RNA General Medicine Non-coding RNA Long non-coding RNA Cell biology Gene Expression Regulation Virus Diseases Heredodegenerative Disorders Nervous System Nucleic Acid Conformation |
| Zdroj: | BioMed Research International, Vol 2015 (2015) BioMed Research International |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | Small nucleolar RNAs (snoRNAs) are appreciable players in gene expression regulation in human cells. The canonical function of box C/D and box H/ACA snoRNAs is posttranscriptional modification of ribosomal RNAs (rRNAs), namely, 2′-O-methylation and pseudouridylation, respectively. A series of independent studies demonstrated that snoRNAs, as well as other noncoding RNAs, serve as the source of various short regulatory RNAs. Some snoRNAs and their fragments can also participate in the regulation of alternative splicing and posttranscriptional modification of mRNA. Alterations in snoRNA expression in human cells can affect numerous vital cellular processes. SnoRNA level in human cells, blood serum, and plasma presents a promising target for diagnostics and treatment of human pathologies. Here we discuss the relation between snoRNAs and oncological, neurodegenerative, and viral diseases and also describe changes in snoRNA level in response to artificial stress and some drugs. |
| Databáze: | OpenAIRE |
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