YY1 cooperates with TFEB to regulate autophagy and lysosomal biogenesis in melanoma
| Autor: | Ran Xiong, Jing Du, Hongquan Wang, Wenyan Ren, Zhuchun Bei, Douglas O'Connell, Hong Wang, Kexin Zhang, Meiying Luo, Yuxue Shang, Yongfei Yang, Fengping Yao |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cancer Research Cellular homeostasis Biology Mice 03 medical and health sciences 0302 clinical medicine Transcription (biology) Lysosome Autophagy medicine Animals Humans Melanoma Molecular Biology YY1 Transcription Factor Basic Helix-Loop-Helix Leucine Zipper Transcription Factors YY1 Activator (genetics) Cell biology Gene Expression Regulation Neoplastic HEK293 Cells 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis embryonic structures Heterografts TFEB Lysosomes Biogenesis Plasmids |
| Zdroj: | Molecular Carcinogenesis. 58:2149-2160 |
| ISSN: | 1098-2744 0899-1987 |
| DOI: | 10.1002/mc.23105 |
| Popis: | Autophagy is a self-proteolytic process that degrades intracellular material to maintain cellular homeostasis. Transcription factor EB (TFEB) is the master activator that regulates the transcription of genes involved in autophagy and lysosomal biogenesis. However, the cotranscriptional factors of TFEB are rarely identified. Here, we found that Yin Yang 1 (YY1) regulated autophagy and lysosome biogenesis in melanoma cells. YY1 cooperates with TFEB to regulate autophagy through controlling the transcription of autophagy and lysosome biogenesis related genes. Moreover, suppression of YY1 enhanced the antitumor efficiency of vemurafenib both in vitro and in vivo. Collectively, these studies identify YY1 as a novel cotranscription factor of TFEB in regulating autophagy and lysosomal functions and suggest YY1 could be a therapeutic target in cancer treatment. |
| Databáze: | OpenAIRE |
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