Cinnamomum burmanini Blume increases bone turnover marker and induces tibia's granule formation in ovariectomized rats
| Autor: | Zairin Noor, Antonius Christianto, Bambang Setiawan, Nia Kania, Nicolaas Budhiparama, Firli Rahmah Primula Dewi, Wahyu Widowati |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Bone turnover medicine.medical_specialty Osteoporosis Bone mesostructure Bone tissue Bone remodeling 03 medical and health sciences Internal medicine Drug Discovery medicine Tibia lcsh:Miscellaneous systems and treatments biology Chemistry Cinnamon lcsh:RZ409.7-999 medicine.disease biology.organism_classification Original Research Article- Experimental 030104 developmental biology Endocrinology medicine.anatomical_structure Complementary and alternative medicine RANKL Ovariectomized rat Osteocalcin biology.protein Cinnamomum |
| Zdroj: | Journal of Ayurveda and Integrative Medicine Journal of Ayurveda and Integrative Medicine, Vol 9, Iss 1, Pp 20-26 (2018) |
| ISSN: | 0975-9476 |
| Popis: | Background Bone fragility and an increase in susceptibility to fracture osteoporosis is characterized by a reduction in bone mass and the micro-architectural deterioration of bone tissue. There is no previous study regarding the effect of Cinnamomum burmanini Blume on osteoporosis. Objective This study was aimed to investigate the effect of C. burmanini Blume on bone turnover marker, mineral elements, and mesostructure of ovariectomized rats. Materials and methods Thirty female Wistar rats were randomly divided into five groups, which included a control group (sham surgery), ovariectomy group (OVX), and ovariectomy groups in the presence of ethanolic extract of C. burmanini Blume (EECB) at doses of 12.5; 25; 50 mg/kg body weight (BW). Analysis of serum C-telopeptide collagen type I (CTX) and osteocalcin (OC) were done by enzyme-linked immunosorbent assay (ELISA). Tibia mineral elements and mesostructure were analyzed by X-ray Fluorescence and Scanning Electron Microscopy, respectively. In silico study was performed by modeling protein structure using SWISS-MODEL server and Ramachandran plot analysis. Results The increase in OC and CTX were significantly attenuated by treatments of EECB. Ovariectomy significantly decreased Cu/Zn ratio compared to sham-operated rats (p Highlights • Administration EECB significantly increased OC and CTX level compared to OVX group. • The ratio of Cu/Zn was lower significantly in OVX rats compared to sham-operated rats. • Hydroxyapatite crystal growth can reach at the highest dose of Cinnamon. |
| Databáze: | OpenAIRE |
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