A randomized controlled trial of a 10week group psychotherapeutic treatment added to standard medical treatment in patients with functional dyspepsia
| Autor: | José M. Quintana, José Luis Cabriada, Miren Orive, Irantzu Barrio, Jesús A. Padierna, Victor Orive, Begoña Matellanes, A. Escobar, Aitor Orive |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Psychological intervention Severity of Illness Index law.invention Randomized controlled trial law Surveys and Questionnaires Intensive therapy Adaptation Psychological Epidemiology medicine Humans In patient Dyspepsia Medical treatment business.industry Intensive treatment Middle Aged Combined Modality Therapy Treatment period Psychotherapy Psychiatry and Mental health Clinical Psychology Treatment Outcome Psychotherapy Group Quality of Life Physical therapy Female Self Report business |
| Zdroj: | Journal of Psychosomatic Research. 78:563-568 |
| ISSN: | 0022-3999 |
| Popis: | Epidemiological evidence suggests an association between psychological factors and functional dyspepsia (FD). Yet few randomized controlled trials (RCTs) of psychological interventions have been conducted for FD. We conducted an RCT to evaluate the efficacy of psychotherapy among chronic FD.One hundred fifty-eight consecutive patients with FD were randomized to medical therapy plus psychotherapy consisted in 8 group and 2 individual sessions focused on teaching techniques for coping with FD (intensive treatment (IT); n=76) or medical therapy alone (conventional treatment (CT); n=82). Patients completed validated self-reported questionnaires before and after the 10-week treatment and 6 months later. Linear mixed-effects models were used, in intention-to-treat analysis.At the end of treatment period, statistically significant improvements were observed for IT compared with CT for dyspepsia-related quality of life (DRQoL). DRQoL mean changes of 6.09 and 3.54 were obtained in IT and CT patients, respectively (p=0.0001); and SS mean changes of 11.55 and 4.57 were obtained in IT and CT patients, respectively (p=0.0013). Those improvements, measured by minimum clinically important difference (MCID), were clinically significant (DRQoL: 77% of the IT patients exceeded the MCID vs. the 45% of the CT; SS: 75% vs. 48%). Six months after treatment, those statistically significant improvements persisted for DRQoL (p=0.0067) and for SS (p=0.0405). Clinical improvements persisted for SS (63% vs. 41%).These findings suggest that adding psychotherapy to standard medical therapy improves short-term outcomes in patients with FD and may have long-term effects as well. The cost-effectiveness of intensive therapy needs to be evaluated. Registration number and name of trial registry: NCT01802710. |
| Databáze: | OpenAIRE |
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