Adrenal Carcinosarcoma Presenting in a Woman With Clinical Signs of Virilization A Case Report With Immunohistochemical and Ultrastructural Findings
| Autor: | Leslie R. Sheeler, James T. McMahon, Carlos Nunez, David J. Adelstein, Howard S. Levin, Diana F. Fischler |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
medicine.medical_specialty Pathology Adrenal Gland Neoplasms Pathology and Forensic Medicine Carcinosarcoma Adrenal Glands Rhabdomyosarcoma medicine Carcinoma Humans Mitotane Neoplasm Metastasis Gynecology business.industry Systemic chemotherapy Virilization Sarcoma medicine.disease Immunohistochemistry Virilism Adrenal Cortex Neoplasms Microscopy Electron Female Surgery Neoplasm Recurrence Local Anatomy medicine.symptom business medicine.drug |
| Zdroj: | The American Journal of Surgical Pathology. 16:626-631 |
| ISSN: | 0147-5185 |
| DOI: | 10.1097/00000478-199206000-00011 |
| Popis: | An adrenal carcinosarcoma is reported in a 29-year-old female presenting with clinical signs of virilization. This is the first reported case of a functioning adrenal carcinosarcoma in the English language literature. The tumor measured 12.5 cm in greatest dimension, weighed 610 g, and consisted of large areas of typical adrenal cortical carcinoma that was, however, interspersed with multiple foci of sarcoma. Rhabdomyosarcomatous elements were identified and confirmed both immunohistochemically and ultrastructurally. After radical resection, the patient received adjuvant mitotane therapy but developed rapid local and metastatic recurrence. Systemic chemotherapy was unsuccessful, and the patient died 8 months after surgery. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|