The junctional adhesion molecule JAML is a costimulatory receptor for epithelial gammadelta T cell activation
| Autor: | Wendy L. Havran, Luc Teyton, Stephanie E. Rieder, Robyn E. Mills, Deborah A. Witherden, Petra Verdino, Olivia Garijo, Ian A. Wilson, Wolfgang H. Fischer |
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| Rok vydání: | 2010 |
| Předmět: |
Keratinocytes
Coxsackie and Adenovirus Receptor-Like Membrane Protein medicine.medical_treatment T cell Amino Acid Motifs Ligands Lymphocyte Activation Article Epithelium Cell Line Mice Phosphatidylinositol 3-Kinases T-Lymphocyte Subsets medicine Animals Receptor Tissue homeostasis Cell Proliferation Wound Healing Multidisciplinary Cell adhesion molecule Cell growth Chemistry Growth factor Epithelial Cells Receptors Antigen T-Cell gamma-delta T lymphocyte Cell biology Mice Inbred C57BL Cytokine medicine.anatomical_structure Epidermal Cells Cytokines Intercellular Signaling Peptides and Proteins Receptors Virus Epidermis Cell Adhesion Molecules Protein Binding |
| Zdroj: | Science (New York, N.Y.). 329(5996) |
| ISSN: | 1095-9203 |
| Popis: | Skin Reaction Lymphocytes in the skin known as γδ T cells provide an important barrier against infection and injury. Unlike classical αβ T cells, less is known about the molecular requirements of γδ T cell activation. Two studies demonstrate that the junctional adhesion molecule–like protein (JAML) is a costimulatory molecule for mouse γδ T. Witherden et al. (p. 1205 ; see the Perspective by Shaw and Huang ) showed that JAML, binding to its ligand Coxsackie and adenovirus receptor (CAR), leads to proliferation, as well as cytokine and growth factor production by γδ T cells. In vivo, JAML-CAR interactions contributed to the wound healing response in mice. Verdino et al. (p. 1210 ; see the Perspective by Shaw and Huang ) present a crystal structure of CAR/JAML, which revealed an intracellular signaling motif similar to that known for the αβ T cell costimulatory receptor that signals through phosphoinositide 3-kinase. |
| Databáze: | OpenAIRE |
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