Gestational age and childhood leukemia: A meta-analysis of epidemiologic studies
| Autor: | Li-Qun Wu, Yong-Yi Bi, Yang-Feng Wang, Hong Wang, Yi-Ni Liu |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Pediatrics
medicine.medical_specialty Childhood leukemia Gestational Age Risk Assessment Infant Newborn Diseases Infant Postmature 03 medical and health sciences 0302 clinical medicine Pregnancy Risk Factors Acute lymphocytic leukemia medicine Odds Ratio Humans 030212 general & internal medicine reproductive and urinary physiology business.industry Infant Newborn Gestational age Hematology medicine.disease Birth characteristics Leukemia Lymphoid Leukemia Myeloid Acute In utero 030220 oncology & carcinogenesis Meta-analysis Acute Disease Female business Infant Premature |
| Zdroj: | Hematology (Amsterdam, Netherlands). 23(5) |
| ISSN: | 1607-8454 |
| Popis: | An increasing amount of evidence shows that childhood leukemia is initiated in utero. Birth characteristics initiated in utero, such as gestational age, may play a role in leukemogenesis. The purpose of our meta-analysis is to explore the association between gestational age and childhood leukemia.Relevant studies up to 21 April 2017 were collected by searching PubMed and EMBASE databases. Subgroup analysis, sensitivity analysis and publication bias assessment were conducted.A total of 13 studies were included. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) for preterm birth and postterm birth were 1.06 (0.98, 1.13) and 1.01 (0.90, 1.13) for childhood leukemia, 1.04 (0.97, 1.11) and 1.03 (0.95, 1.12) for acute lymphocytic leukemia (ALL), 1.20 (1.00, 1.44) and 1.20 (1.00, 1.43) for acute myeloid leukemia (AML), compared with full-term birth. Study type and study region were the reasons behind the heterogeneity. In subgroup analyses, the summary ORs with 95% CI for childhood leukemia and ALL were 1.23 (1.07, 1.41) and 1.21 (1.06, 1.39) for postterm birth in cohort studies. No significant changes in sensitivity analyses and no publication bias were observed in our analysis.Our results suggest that both preterm and postterm infants have an elevated risk of developing AML. In addition, postterm birth increased the risk of childhood leukemia and ALL in cohort studies. However, more studies are warranted to validate these results and explore the biologic mechanisms underlying these relationships. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|