Chitosan/sodium tripolyphosphate nanoparticles as efficient vehicles for antioxidant peptidic fraction from common kilka
| Autor: | Mohammad Reza Soleimani, Seyed Fakhreddin Hosseini, Maryam Nikkhah |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Antioxidant
Protein Hydrolysates Sodium medicine.medical_treatment chemistry.chemical_element Nanoparticle Fraction (chemistry) Peptide 02 engineering and technology 010402 general chemistry 01 natural sciences Biochemistry Antioxidants Excipients Chitosan chemistry.chemical_compound Microscopy Electron Transmission Polyphosphates Structural Biology Spectroscopy Fourier Transform Infrared medicine Animals Molecular Biology chemistry.chemical_classification Chemistry Fishes General Medicine 021001 nanoscience & nanotechnology 0104 chemical sciences Kinetics Transmission electron microscopy Nanoparticles Peptides 0210 nano-technology Nuclear chemistry Ionotropic effect |
| Zdroj: | International Journal of Biological Macromolecules. 111:730-737 |
| ISSN: | 0141-8130 |
| DOI: | 10.1016/j.ijbiomac.2018.01.023 |
| Popis: | Fish-purified antioxidant peptide (AOP)-loaded chitosan nanoparticles (CSNPs) were synthesized based on the ionotropic gelation between CS and sodium tripolyphosphate (TPP). The ζ-potential showed an earlier rise and later decrease with increasing concentrations of AOP. Transmission electron microscopy (TEM) images also revealed roughly uniform spherical-shaped nanoparticles with diameter of100 nm. Molecular interactions among the components of the NPs and peptides were confirmed by FT-IR spectroscopy. Thermo-gravimetric analysis (TGA) results showed the improved thermal stability of the AOP-loaded CSNPs compared with free peptides. The maximum peptide encapsulation efficiency was determined to be 71.16% and the in vitro release of peptides from CSNPs was in a controllable manner. Furthermore, assessing the free radical scavenging ability of the peptide-encapsulated NPs and the reducing power assay, confirmed the efficacy of such nanosystem in retaining the antioxidant activity of fish-derived peptides. |
| Databáze: | OpenAIRE |
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