Lean Women on Metformin and Oral Contraceptives for Polycystic Ovary Syndrome Demonstrate a Dehydrated Osteosarcopenic Phenotype: A Pilot Study
| Autor: | Eleni Kandaraki, Charikleia Stefanaki, Dario Boschiero, Flora Bacopoulou, Evanthia Diamandi-Kandarakis |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
medicine.medical_specialty endocrine system diseases Body water bio-impedance lcsh:TX341-641 030209 endocrinology & metabolism Inflammation Pilot Projects Article 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Internal medicine Abdominal fat Medicine Humans Hypoglycemic Agents oral contraceptives osteosarcopenia body composition 030219 obstetrics & reproductive medicine Nutrition and Dietetics Glycogen business.industry pcos nutritional and metabolic diseases Polycystic ovary Phenotype Metformin 3. Good health Endocrinology chemistry polycystic ovary syndrome Female medicine.symptom business lcsh:Nutrition. Foods and food supply Body mass index Food Science medicine.drug Contraceptives Oral |
| Zdroj: | Nutrients Volume 11 Issue 9 Nutrients, Vol 11, Iss 9, p 2055 (2019) |
| ISSN: | 2072-6643 |
| Popis: | Scarce data exist on the body composition of lean women with polycystic ovary syndrome (PCOS) on treatment with metformin and oral contraceptives (OCs). Thirty-four lean (body mass index 18.5&ndash 24.9 kg/m2) women (17 with PCOS on metformin and OCs treatment for six months and 17 controls) aged 18&ndash 40 years were assessed for body composition parameters (fat, muscle, glycogen, protein masses, bone masses, and body water compartments) and phase angles. PCOS patients demonstrated lower muscle, glycogen and protein masses (U = 60, p = 0.003), along with a lower bone mineral content and mass (U = 78, p = 0.021 U = 74, p = 0.014) than their healthy counterparts, while total and abdominal fat masses were similar between the two groups. PCOS patients also exhibited increased extracellular body water (U = 10, p < 0.001) and decreased intracellular water, compatible with low-grade inflammation and cellular dehydration. Key differences in body composition between women with PCOS and controls demonstrated an osteosarcopenic body composition phenotype in PCOS patients. A confirmation of these findings in larger studies may render osteosarcopenia management a targeted adjunct therapy in women with PCOS. |
| Databáze: | OpenAIRE |
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